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Lastly, NBDHEX is not a substrate for the P-glycoprotein export pump but promotes cysteine-dependent apoptosis in cells overexpressing P-gp and may be used to treat P-gp-positive tumors [165]
This includes neurodegenerative diseases such as Alzheimers, as well as mental health conditions like schizophrenia
The loss of GSH through the membrane may in turn depend on membrane oxidative stress, because oxidative stress causes lipid peroxidation of cell membrane, leading to altered membrane permeability and transport functions and consequently increased GSH efflux [36]
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Antiox Redox Signal 20, 11261167
