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Patients should be counseled that these symptoms, while uncomfortable, are generally not dangerous and tend to resolve over time

This suggests the triple receptor mechanism does not dramatically worsen constipation compared to single or dual receptor approaches

MACE includes non-fatal heart attack, non-fatal stroke, or cardiovascular death

Semaglutide may be inappropriate for people with label-listed contraindications, certain pregnancy or breastfeeding situations, or medical histories that raise concern for serious gastrointestinal, gallbladder, pancreatic, kidney, or mental health complications

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### Conservative 24-Week Titration Protocol | Weeks | Weekly Dose | Notes | |-------|-------------|-------| | 14 | **1mg** | Starting dose