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This difference becomes especially important in the case of semaglutide

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1 This dual effect is hypothesized to impact glycemic control and weight loss more than GLP-1 receptor agonism alone due in part to the prevalence of glucose-dependent insulinotropic polypeptide receptors in adipose tissue and the brain

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The loading of the resulting resin is measured to be 0.26 mmol/g by quantitative NMR

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13 In addition to being recommended in patients with ASCVD, GLP-1 receptor agonists are recommended for consideration as an add-on to metformin in patients without established ASCVD in whom there is a compelling need to minimize hypoglycemia, minimize weight gain, or promote weight loss

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