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Ein Nachteil sind allerdings die Beschwerden, die bei vielen Patientinnen und Patienten whrend der Einnahme auftreten
[DOI] [PMC free article] [PubMed] [Google Scholar] 102.Arnes L., Gonzalez N., Tornero-Esteban P., Sancho V., Acitores A., Valverde I., Delgado E., Villanueva-Penacarrillo M.L
Slows down digestion

Further reading on observed adverse signal profiles from the investigational phase 2 programme is available in the Retatrutide Side Effects: Detailed Guide with Clinical Trial Insights 2026 article, which summarises published tolerability data for research planning purposes

If you feel persistently down, numb, or lose interest in life, bring it up quickly with your provider

However, researchers should be aware that gastric emptying is most significantly slowed in the 24 to 48 hours following tirzepatide injection, which is when berberine absorption may be most variable
