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This paper reviews the physiological, pharmacologic, and clinical foundations linking GLP-1 RA therapy to reproductive outcomes

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Both human and animal studies reported inconsistent BP response to acute administration but showed hypotensive effect of chronic administration of GLP-1/ GLP-1 RAs

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GLP-1 receptor agonists can reduce thirst signals and increase fluid loss through gastrointestinal changes, making intentional hydration critical during treatment

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