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Statements Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

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To address this issue, the type II collagen-binding peptide WYRGRL, which exhibits high affinity for cartilage extracellular matrix components, can be employed to functionalize drug-loaded NPs [29]

All stock solutions were prepared by dissolving them in de-ionized water, except for tolbutamide, which was dissolved in ethanol

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