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The use of this medication in patients with severe renal impairment or on dialysis is not recommended

Semaglutide overview: this article covers what it is, how it works mechanically, FDA-approved indications, common and serious side effects including the class boxed-warning context, April 2026 cost landscape, and the FTO, GLP1R, MC4R, and TCF7L2 variants that shape every GLP-1 response