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Overall risk of bias for each trial was considered low if all domains were at low risk of bias, and high if at least one domain was at high risk of bias

Increased HRV indicates better stress management and a calmer nervous system

Effects take weeks to fully manifest, so consistent supplementation matters more than short-term high doses

Patients considering compounded GLP-1 treatment should confirm current availability through Novi and discuss medication status, risks, and alternatives with a licensed clinician before treatment begins