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Brain Behav Immun 55:8292 Shan Y, Tan S, Lin Y, Liao S, Zhang B, Chen X, Wang J, Deng Z, Zeng Q, Zhang L, Wang Y, Hu XQ, Qiu W, Peng L, Lu ZQ (2019) The glucagon-like peptide-1 receptor agonist reduces inflammation and blood-brain barrier breakdown in an astrocyte-dependent manner in experimental stroke

Semaglutide is also approved for weight management in people battling obesity, especially those with a Body Mass Index (BMI) of 30 or greater, or a BMI of 27 or above when paired with weight-related conditions such as high cholesterol, type 2 diabetes, or hypertension

Symptoms for acute kidney injury may include reduced urine output, swelling, seizures and coma

That doesnt make the drug unsafe, but it does raise questions that only long-term studies can answer

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We also review effects of antidiabetic medications on LUT function
