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Although degradation-resistant GLP-1R agonists have minimal effects on blood vessels (79), they increase HR and reduce cardiac inflammation and infarct size in animals with experimental myocardial infarction (75, 80)
This drug has been underutilized in PTD-associated glycemic dysfunction, although it may be beneficial for diabetic patients requiring treatment with risperidone, paliperidone, or some antidepressants that are often associated with hyperprolactinemia
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Many GLP-1 users need the higher end of supplementation
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Meanwhile, tirzepatide research is expanding into other areas, such as sleep apnea and renal health
