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Semaglutide not only consistently reduces energy intake (Blundell et al., 2017) but also achieves substantial weight loss, up to approximately 15% in individuals who are overweight or obese (Wilding et al., 2021)

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In this review I aim to re-examine the contested concept of food addiction as a disease in the context of emerging GLP-1based obesity pharmacotherapies, integrating perspectives from neurobiology, societal impacts, and early evidence for their potential application in other substance-use disorders

Similar to a previous clinical study [18], these peptides significantly reduced lean mass, indicating that these GLP-1 analog peptides suppressed both fat and lean mass (Fig

Among placebo-controlled trials of patients with overweight or obesity, treatment with tirzepatide at 10 mg per week resulted in 82% and 96% of individuals with and without T2D achieving 5% or more weight loss by 72 weeks, respectively (efficacy estimands)

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