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GLP-1 is a target for treatment of diabetes because of the primary peripheral functions of inducing insulin secretion from pancreatic cells, gut emptying and inhibiting glucagon secretion which results in lower blood glucose levels ( GLP-1 can also be produced by neurons in central nervous system (CNS) ( Pathogenesis of AD Amyloid plaque Amyloid beta (A) is a peptide with a molecular weight of 4 KDa and a length of 40-42 amino acids ( 2+ channels and AMPA (-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors, to which the neurotransmitter glutamate binds, so A is the most neurotoxic form ( Neurofibrillary tangles Tau is a microtubule-associated protein and mainly found in the axonal compartment (36, 37)

performed an analysis to assess the effects of oral and injectable semaglutide versus placebo on MACEs in subjects with T2DM in a combined population from SUSTAIN 6 and PIONEER 6 [35]

Biliary disease was numerically higher, but did not achieve statistical significance in the primary analysis (aHR 1.5, 95% CI: 0.9-2.5)