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Nielsen JB, Abild CB, Pedersen AM, et al

Patients who follow gradual titration schedules and eat smaller, lighter meals report significantly less discomfort than those who jump to higher doses rapidly or maintain their regular portion sizes

These drugs are intended to help regulate blood sugar levels and promote weight loss by mimicking the effects of the GLP-1 hormone, which stimulates insulin production and slows down digestion

However, since most of the Pdx1-Cre;Trp53 R172H ;Rb f/f mice develop insulinoma only at the age of over 180 days and those mice die within 2 weeks after presenting with hypoglycemia as previously reported 22 , it is challenging to employ a larger number of the mice to complete our comparative protocol between [ 18 F]FB(ePEG12)12-exendin-4 and [ 68 Ga]DOTATOC PET/CT scans