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Millions of patients with diabetes have achieved better glucose control
This neither supports nor refutes potential benefit

Trapp & Cork, 2015 )

Time to peak concentration for the oral agent is 1 hour and I suppose the trial was designed to have the concentrations at their highest when a patient begins to eat
Propensity score weighting was also performed for this subset of patients (eFigure 3 in Supplement 1)

Tirzepatide Associated with Reduced Albuminuria in Participants With Type 2 Diabetes: Pooled Post Hoc Analysis from the Randomized Active- and Placebo-Controlled SURPASS-15 Clinical Trials
