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The absolute bioavailability of sitagliptin is approximately 87%

They are significantly higher in price than older, conventional diabetes treatments such as biguanides like metformin as Mounjaro and Ozempic are still on patent and are biologics, which tend to be more expensive given their complexity

Tirzepatide's incretin-based action enhances meal-related insulin secretion and suppresses appetite through gut-brain axis signaling, while berberine's AMPK activation may improve baseline insulin sensitivity and hepatic glucose regulation