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GLP-1 Clinical Trials Show Promising Reduction in Body Weight The most cited GLP-1 study is the STEP 1 trial , which evaluated semaglutide, the active ingredient in Wegovy, in non-diabetic adults with obesity

If you have a known predisposition to GLP-1-related nausea or GI intolerance (either from previous experience or genetic insights), communicating this to your provider before flu season helps establish a clear illness-management plan

The mechanism appears to be GLP-1 receptor activation in the brain's reward pathways, which attenuates dopamine release in the nucleus accumbens and reduces the reward signal from alcohol

According to the Centers for Disease Control and Prevention, obesity is a chronic disease linked to multiple health risks

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GLP-1 medications also have an appetite suppressing effect (anorexigenic effect), so pairing Ozempic and coffee or Zepbound and coffee and other GLP-1 medications and coffee could amplify this effect, thereby presenting a challenge to consuming a nutrient-dense diet