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Tripleagonists such as retatrutide appear to exceed both single and dualagonists in average bodyweight reduction in early trials

GLP-1 therapies work best when combined with lifestyle modifications

Patients have reported decreased interest in alcohol and nicotine when taking GLP-1s, and observational studies have shown an association between treatment with GLP-1 medication and lower risk of alcohol and cannabis use disorders, opioid overdose, and alcohol-related hospitalization

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Patients with cirrhosis were older and in care longer than patients without cirrhosis (Table 1)

Peyrot M, Rubin RR, Kruger DF, Travis LB