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Earlier use of pharmacotherapy is encouraged Medications should be considered early, especially in patients withor at high risk ofobesity-related complications

Metabolic alterations have been studied in the myocardium of heart failure (HF) patients

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These medications exert (in)direct hepatic actions by reducing steatosis, attenuating inflammation, and potentially reversing fibrosis, while simultaneously addressing systemic metabolic abnormalities including excessive obesity, insulin resistance, and cardiovascular risk

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