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But one consequence that catches many patients off guard is what happens to their skin.

The Pharmacovigilance Risk Assessment Committee (PRAC) of the European Medicines Agency (EMA) is reviewing data on the risk of suicidal thoughts and thoughts of self-harm with glucagon-like peptide-1 agonist (GLP-1a), including Ozempic (semaglutide), Saxenda (liraglutide) and Wegovy (semaglutide)

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Gut, 65(3), 426-435

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At the same time, payer policies often require discontinuation of GLP-1 therapy when a patients BMI drops below a set threshold, inadvertently triggering a frustrating cycle of weight loss and regainthe so-called yo-yo effect. This not only impacts ongoing adherence and persistence but also undermines the long-term cost-effectiveness of these therapies for healthcare systems