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Researchers also examined major adverse CV events in patient subgroups on the basis of major adverse CV event rates in the placebo group, the presence or absence of CVD, HbA1c level, trial duration, treatment dosing interval, structural homology to human GLP-1 or exendin-4, BMI, age and eGFR

We excluded studies on drug-drug interactions between GLP1RAs and anti-hyperglycemic medications

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[DOI] [PMC free article] [PubMed] [Google Scholar] 43.Bodhale DW, Nisar A, Afzulpurkar N

A dose that produced significant appetite suppression and weight loss three months ago may be insufficient now that your body has adapted

The medication manages hunger