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The appetite-suppressing effect of GLP-1 is mediated by its action in the brain, whereas its glucose-lowering effect is mainly attributed to enhancement of glucose-stimulated insulin secretion [74]

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Bluestein (and connected them to mitochondrial issues) in a Bendy Bodies podcast (approximately 21 minutes in)

While GLP-1 drugs were first approved to treat type 2 diabetes in 2005, the class of medications have become more popular in recent years, especially as Wegovy (semaglutide) was approved for weight loss in June 2021

1.Ponmani C, Banerjee K

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