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Another study in a GIP receptor knockout model showed decreased bone strength and cortical thickness and increased bone resorptionbut paradoxically, an increased number of osteoblasts and a reduced number of osteoclasts [49]

Ultimately, understanding the nuances of these therapies allows providers to match the right drug to the right patient

Effects of glucagon-like peptide 1 (GLP-1) analogs in the hippocampus

Not to get too deep into the science, but a PPAR agonist delivered selectively because of GLP1 and GIP receptors may mean that we can see the insulin sensitizing benefit of this drug class without the negative side effects that prior meds in this class have suffered from