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These changes create a net positive effect on urinary health that grows stronger the longer treatment continues

Dinh Tran, MD What are GLP-1 injections, and how do they work for weight loss

Clinical trials demonstrated that patients who followed gradual escalation experienced significantly fewer gastrointestinal side effects compared to those on faster schedules

Animal models of colitis have demonstrated that GLP-1 receptor activation may reduce intestinal inflammation through multiple mechanisms, including modulation of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-) and interleukin-6 (IL-6), enhancement of intestinal barrier function, and reduction of oxidative stress

Source: eClinicalMedicine (The Lancet), 2025 53 T1D participants