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Description
Both trials were led by the same investigator, Ania Jastreboff, who also led the retatrutide Phase 2 obesity trial

NICE guidance emphasises that pharmacological interventions should be part of a multicomponent approach that includes dietary modification, increased physical activity, and behavioural strategies for optimal and sustainable outcomes

As with other incretin therapies, retatrutide is expected to be contraindicated in patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2

Additives and excipients warrant attention

Most uniquely, its glucagon receptor agonist activity increases energy expenditure, pushing the body to burn more calories

A Call to Action: Restoring and Strengthening Americas Patient Safety System serves as a roadmap for policymakers and regulators to uphold the gold standard system that protects Americans from untested and unsafe medicines
