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If an arterial Doppler signal is completely lost, then the limb is considered non-viable
Understanding the reasons behind this phenomenon is essential for optimising treatment outcomes
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However, current evidence does not strongly justify the cessation of GLP-1 RAs based on suicidality concerns
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Moreover, mice with targeted inactivation of GLP-1R in autonomic neurons targeted by Phox2b, including the nodose ganglion, exhibit impaired glucose homeostasis, accelerated gastric emptying, and increased levels of GLP-1, glucagon, and insulin, supporting the importance of vagal afferent GLP-1Rs for metabolic homeostasis [520]
