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Recent findings Emerging research indicates that IR and related metabolic abnormalities are highly prevalent in BD and are associated with illness progression, cognitive impairment, and reduced treatment response

95% CI: 1.281.67), while no statistically significant difference was observed between the two groups for stroke (HR: 1.17

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Evidence now warrants a focus on the beta cell itself and how to avoid its dysfunction, which is putatively caused by cytokine-driven inflammation and other stress factors, leading to low insulin-secretory capacity, autoantigen presentation and immune-mediated destruction