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To determine the effect of C3G on each cell line, two cell lines were treated separately with C3G

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Increased gene expression of connective tissue growth factor (CTGF), a profibrotic cytokine in DKD rats was reduced by EMPA + LINA

This effect appeared to be mediated by antioxidant mechanisms involving GSK3 phosphorylation 156 , and it was also associated with a reduction of measures of memory impairment in mice 157

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