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Semaglutide's mechanismslowing gastric emptying and enhancing satietycreates conditions for sustained weight loss that may compound mood benefits over months

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Patterson JT, Ottaway N, Gelfanov VM et al (2011) A novel human-based receptor antagonist of sustained action reveals body weight control by endogenous GLP-1

[1] Clinical trials demonstrate that most patients experience substantial weight loss during treatment, with average reductions of 15-21% of initial body weight at maximum doses by approximately 72 weeks, as shown in the SURMOUNT-1 trial

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In trials involving diabetics, the incidence of hypoglycemia was 6.2% in Wegovy-treated patients and 2.5% in placebo-treated patients