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The human body naturally makes a hormone called GLP-1, or Glucagon-Like Peptide-1

These hormonal shifts may contribute to appetite regulation and improved postprandial metabolism

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doi: 10.1016/j.ebiom.2025.106119

While most side effects are manageable and temporary, there are more serious risks to be aware of: Pancreatitis Though rare, this condition can be serious

However, an exposure-response modeling analysis suggested that an initial deterioration in A1C may be seen when switching from dulaglutide 1.5 mg once weekly or liraglutide 1.2/1.8 mg once daily to the initial recommended 0.25 mg once-weekly dose of subcutaneous semaglutide (62)