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Combining testosterone replacement with GLP-1 receptor agonists like semaglutide involves complex metabolic and hormonal interactions

Large-bowel obstruction (LBO) is an emergency condition that requires early identification and intervention

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Participants 43365 adults (18 years) with type 2 diabetes who used a GLP-1 receptor agonist or SGLT-2 inhibitor within 30 days before upper gastrointestinal endoscopy

As we await prospective data, clinical practice should consider the difference between abrupt stop vs gradual taper when counseling patients about expectations after therapy

However, data have yet to conclusively establish an association