top-selling glp-1 medications in the u.s. 2025 Top 10 Best-Selling Drugs Q1 2025’s Breakthrough GLP-1 Obesity Treatments:

Gastroparesis, a condition in which the stomach empties food too slowly, worsens significantly with GLP-1 medications because these drugs slow gastric motility as part of their mechanism

Segments in the study include areas of indication, application, distribution channel, and regions

Flick the syringe gently with your finger to move bubbles to the top (near the needle), then push the plunger slightly to expel them

In the intestinal L-cells, proglucagon is cleaved by the enzyme prohormone convertase 1/3 to produce GLP-1, along with other peptides including GLP-2 and glicentin

For context, Medicaid spending on GLP-1 drugs in Pennsylvania was $1.3bn in 2025 - a whopping twice as much as the previous year

Outcomes regarding HF events are summarised in Table 1