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Monitor Consistency Stick to your medication schedule

Patients in remission or with mild, well-controlled disease may tolerate semaglutide better than those experiencing active flares or stricturing complications

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Consequently, dual GLP-1/glucagon agonists survodutide, and triple GLP-1/GIP/glucagon agonists retatrutide are not spared gastrointestinal adverse events, as glucagon related pro-emetic signaling may offset any potential tolerability benefits from GIP agonism ( The contribution of amylin-based therapies to gastrointestinal adverse events remains less clear