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Like other GLP-1 drugs, Foundayo can cause side effects such as nausea, constipation, diarrhea, vomiting, abdominal pain, and headache, according to the FDA

Emerging Safety Concerns Recent research has identified new safety considerations beyond traditional gastrointestinal effects

For example, drug development targeting the repair of intestinal barrier function can promote the proliferation and differentiation of intestinal epithelial cells and increase the expression of intercellular tight junction proteins to fundamentally improve intestinal barrier function and reduce the occurrence of inflammation

Moreover, combination therapies have demonstrated significant advantages, such as Novo Nordisks CagriSema (semaglutide + cagrilintide), which shows superior glycemic control and weight reduction effects compared to semaglutide alone, demonstrating that combination therapy can achieve more than the sum of its parts while reducing side effects

The use of sodium-glucose co-transporter-2 inhibitors or glucagon-like peptide-1 receptor agonists versus sulfonylureas and the risk of lower limb amputations: a nation-wide cohort study