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Overweight and obesity management (NG246) NICE

Given the increasing evidence of alternative receptor-independent sources of cAMP (from intracellular sAC) (29, 30), we hypothesized that GLP-1(2836) mediates its GLP-1Rindependent effects through sAC

Less Common but Serious Side Effects Some less common but more serious GLP-1 side effects are worth being aware of: Pancreatitis (inflammation of the pancreas) Gallbladder problems (including gallstones) Acute kidney injury (usually as a result of severe dehydration from vomiting or diarrhea) Diabetic retinopathy worsening (particularly in patients with rapid improvement in blood sugar control) Hypoglycemia (when combined with other diabetes medications like sulfonylureas or insulin) All GLP-1 medications also carry a warning regarding a theoretical risk of medullary thyroid carcinoma, based on animal studies

Studies in humans In response to the increasing reports of GLP1RA exposure in pregnancy, several observational studies (summarised in Table 3) have been conducted screening large databases of pregnancy records to uncover the impact of perinatal GLP1RA exposure on fetal outcomes including congenital malformations and pregnancy loss

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However, researchers involved in the field said some inflammation-related biomarkers showed modest changes that continue to attract scientific attention