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Retatrutide has not received FDA approval and is currently only available through clinical trials

If approved, OAV101IT could provide an alternative to IV-administered onasemnogene abeparvovec (Zolgensma) for the treatment of SMA, particularly for patients who may not qualify for IV administration due to weight restrictions

Use of an SGLT2 inhibitor lowered the risk for HF hospitalization or CV death compared with adults receiving placebo (HR = 0.77

This necessitates careful monitoring and likely medication adjustment

Semaglutide operates primarily through its action on the GLP-1 receptors, which are not only located in the pancreas but also widely distributed in the gastrointestinal tract

Study participants must ensure they stay well-hydrated throughout the study