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doi: 10.1093/mutage/gen011

GLP-1 medications can reduce your sense of thirst a meaningful risk in a hot climate like Las Vegas

GLP-1 induced activation of PKA increases Pdx1 expression and translocation of Pdx1 to the nucleus, where Pdx1 binds to the insulin promoter to initiate insulin expression and synthesis (Figure 5) [490,524]

On the other hand, Saxenda is given as a once-daily dose

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One area that has attracted academic discussion, press coverage, and significant biotechnology/pharma R&D investment is concern about undesirable, collateral skeletal muscle mass (SMM) loss, and presumably by extension, loss of strength and function in people taking GLP-1 medications