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How should GLP-1 medications be integrated into treatment for obesity
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The anatomical distribution of GLP-1R throughout the reproductive system and several preclinical evidence support that GLP-1 can modulate the HPG axis activity at different levels, thus connecting reproductive functions, metabolic system, nutrition, and energy homeostasis mechanisms
More recently, GLP-1s have been FDA-approved for weight management, offering a solution for those looking to achieve significant, sustainable weight loss
The physiological profile of METRNL is nevertheless highly attractive
Chuang CC, Wang K, Chang CK, et al
