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Description
Logistic regression was performed using both Python (Python Software Foundation, Wilmington, Delaware, USA) and R 3.4.4 software (R Foundation for Statistical Computing, Vienna, Austria) to ensure the outputs matched, and the order of the rows in the covariate matrix was randomised to eliminate this bias

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Understanding that plateaus represent a normal physiological response rather than medication failure helps maintain realistic expectations and treatment adherence

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We now have early reports and real-world data suggesting that a subset of patients experience increased shedding after starting or increasing these medications

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