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The glucagon receptor agonism component is relatively novel in this context, and its downstream effects on the hypothalamic-pituitary-gonadal axis which governs sex hormone production have not been formally studied in published retatrutide trials

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The primary concerns include intensified gastrointestinal side effects (nausea, vomiting, diarrhoea), increased risk of nutritional deficiencies, challenges maintaining adequate protein intake for muscle preservation, and potential dehydration or electrolyte imbalances

[DOI] [PMC free article] [PubMed] [Google Scholar] 14.Hojberg PV, Vilsboll T, Rabol R, Knop FK, Bache M, Krarup T, Holst JJ, Madsbad S

In 2025, major US retailers expanded shelf placement for high-protein GLP-1 companion nutrition products as consumers sought convenient solutions supporting protein intake, satiety management, and daily nutritional adequacy during weight-management therapy routines, supporting GLP-1 supplement market growth