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Basha, Soha M., et al

clinicians should consult trial protocols, seek endocrinology input, and document clinical rationale with informed consent

All patients were closely tracked for up to 5 years for any occurrence of the outcome of interests

Glucagon signaling is associated with: Increased energy expenditure Enhanced fuel mobilization A shift toward higher metabolic output Greater emphasis on energy utilization pathways From a systems physiology and neurobiological perspective, this combination may bias the organism toward a more output-focused metabolic state rather than a reward-oriented state

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[DOI] [PubMed] [Google Scholar] 29.Diamant M, Van Gaal L, Guerci B, Stranks S, Han J, Malloy J et al