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Personalized Restart: The Role of Genetic Insights in Your Restart Plan Not all patients respond to semaglutide equally, and genetic variation plays a measurable role in treatment outcomes

[DOI] [PMC free article] [PubMed] [Google Scholar] 26.Huang D., Refaat M., Mohammedi K., Jayyousi A., Al S.J., Abi K.C

In the ESSENCE trial involving participants with biopsy-confirmed MASH and stage 2 or 3 fibrosis, over half of whom had T2DM, interim analysis at 72 weeks showed 63% of those treated with semaglutide 2.4 mg weekly achieved resolution of steatohepatitis without worsening of fibrosis, compared with 34% in the placebo group

Based on the human, societal, and financial burdens of obesity, as well as the costs and adherence challenges of GLP-1 therapy, more comprehensive weight management programs and research on their optimal use are needed in healthcare
