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Other studies may be looking at retatrutides benefits beyond just weight and may need patients with other health conditions, like kidney disease or Type 2 diabetes

The mechanism isn't fully understood, but it may be related to the glucagon receptor activity, which is the component that sets retatrutide apart from dual agonists like Mounjaro

doi: 10.3945/jn.113.174615 8 DaviesMJArodaVRCollinsBSGabbayRAGreenJMaruthurNMet al

The Phase 2 data shows averages, and averages hide enormous individual variation

DXA data from the STEP-1 and SURMOUNT-1 trials show meaningful lean mass reduction during GLP-1-driven weight loss: approximately 9.7% of total lean tissue with semaglutide in STEP-1, and 10.9% with tirzepatide in SURMOUNT-1

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