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Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity (STEP 4)

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SGLT2is and GLP-1 RAs consistently demonstrate cardiovascular and nephroprotective effects [11]

If reduced genital blood flow is the primary issue, PDE-5 inhibitors (the same class of medications that includes sildenafil) could theoretically help by increasing blood flow to genital tissue

Renal/hepatic function & drug interactions Most patients do not need dose adjustments

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