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Can I continue GLP-1 therapy if I've had kidney stones before

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Molecular-level observations also add to the evidence that GLP-1 is active in the brain

Retatrutide is an investigational triple incretin receptor agonist that simultaneously activates GLP-1, GIP, and glucagon receptors, producing appetite suppression, enhanced insulin secretion, and increased energy expenditure, though long-term safety and cardiovascular outcome data are not yet available

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The enhancement of active endogenous GLP-1 leads to increased insulin but reduced glucagon secretion, in addition to delaying gastric emptying and supressing appetite ( Pathophysiology of T2D is characterized by predominant insulin resistance than impaired insulin secretion in Caucasians whereas impaired insulin secretion rather than insulin resistance predominates in Asians ( It is apparent that the therapeutic effects of DPP-IV inhibitors in Asians are more pronounced compared with Caucasians