glp-1 r Understanding receptor agonists and their impact on drug discovery GLP-1R Signaling and Functional Molecules

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2 It is possible that lipidation at certain sites can create steric hindrance that does not allow GLP-1Rs to capture ligands directly from the albumin, but only to trap free ligands released by the albumin

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11,12 The risk of complications in SUSTAIN-6 was highest among patients with pre-existing diabetic retinopathy and rapid HbA1c reduction, suggesting that the findings reflect the early worsening of diabetic retinopathy that can occur with any method of lowering glucose, rather than direct retinal toxicity from GLP-1 RAs

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