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Semaglutide was originally developed for type 2 diabetes, but clinical evidence now supports its use for chronic weight management in people without diabetes who have overweight or obesity

Single-kidney status requires careful evaluation before starting semaglutide

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The results prompt safety concerns for GLP-1RAs, especially with high dose administration, regarding gastrointestinal adverse events

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their use should be consistent with individual physiological needs and evidence-based practice, and the process should be managed by a qualified health professional.