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For example, the nonbenefit for lixisenatide in the ELIXA trial may be partially attributable to its extremely high-risk cohort, where 100% of participants had established CVD and an ACS within the last 180 days [53]

Additionally, in the analyses of WL after surgery and before treatment, the intercepts were also positive for age with p-value = 0.07 and p-value = 0.09 for GLP-1RAs and placebo treatment groups, respectively, suggesting that older age may be associated with slightly reduced WL

Perhaps switching from morning to evening, or tying the injection to a more reliable routine, would improve adherence
Conservation of Glucagon Like Peptide-1 Level With Liraglutide and Linagilptin Protects the Kidney Against Angiotensin II-Induced Tissue Fibrosis in Rats