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said, The incidence of thyroid cancer in semaglutide-treated patients was less than 1%, suggesting no significant risk. More specifically, both semaglutide and tirzepatide are contraindicated for patients with a personal or family history of medullary thyroid cancer (MTC) or multiple endocrine neoplasia type-2 (MEN2)

Semaglutide is not recommended for anyone who has a history of medullary thyroid carcinoma (a rare form of thyroid cancer), or a condition called Multiple Endocrine Neoplasia syndrome type 2

doi: 10.4093/dmj.2018.0070

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A 2024 study found that patients taking semaglutide medications were significantly more likely to develop NAION compared to certain other diabetes medications, raising concern about a possible association between GLP-1 drugs and optic nerve injury