oasis 1 oral semaglutide 50 mg nejm 2023 obesity Once-Weekly in Adolescents with Once-Weekly Semaglutide in Adults with

Purpose-built for physicians GLP-1s show clear signal of reduced rheumatoid arthritis, gout, osteoarthritis risks Key takeaways: Use of GLP-1 receptor agonists in diabetes was associated with reduced risk for RA and gout

Testing after a year catches any developing issues before they become problematic

GLP-1 discontinuation was also associated with lower HbA1c and higher weight at time of initiation

While the prescription drug is primarily used to lower blood sugar levels, it has also shown considerable potential in aiding weight loss

Sleep disruption Nausea or new eating patterns may interfere with your usual sleep quality

Mounjaro (tirzepatide) Also a once-weekly injection, but tirzepatide targets both GLP-1 and GIP receptors a dual-action approach that has produced the strongest weight loss results seen in clinical trials to date (2025% average loss at the highest dose)