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Historically, endocrinologists and internists dominated the GLP-1 prescription scene, but their share dropped from 93% in 2020 to 83% in 2025

b , f , j , Heatmap showing gene expression z-scores of all significantly up- or down-regulated genes for each treatment relative to vehicle in the liver ( b ), eWAT ( f ) and skeletal muscle ( j )

Clinical indicators like an A1C lab result of 6.5 or higher are part of the requirements

compared dulaglutide + CRD with CRD alone and suggested potential advantages in certain fat distribution and metabolic risk markers

It is estimated that as many as half of diabetics have underlying NAFLD, with a higher risk of progression to NASH with fibrosis than non-diabetics

However, medication alone is not the full solution